Ghana is a beautiful, very safe country, so the other answers here are accurate. It’s hard not to have a wonderful experience there. Stay healthy – be very careful about the water you ingest. Buy bottled or sachet water. Also be careful about where you swim. I took a dip in the Volta River and got a very painful parasite.
Also be mindful of the areas where malaria is common, and try to limit your time outdoors in the early evening when mosquitoes are out. Malaria is a big deal for people who can’t afford a regular trip to the pharmacy to spend 30 cedis on a box of Coartem, but as soon as you start to feel any flu symptoms, pop a dose – your symptoms should ease up within a few hours. Bring some Coartem and a dewormer home with you in case you get delayed malaria symptoms, because it may be more difficult to get it outside of the country.
All these antibiotics can destroy your digestive system. Plan on the possibility of dealing with diarrhea for months after you get home.
Don’t make promises you can’t keep because some Ghanaians will become attached to you, either because they like you or maybe see you as a path to a better future. If you meet people who open up to you, don’t lead them on and allow them to think you are going to help them if you have no intentions of doing so.
Many Ghanaians (especially the young adults) dream about seeking opportunity abroad. Being a foreigner, you will be seen as a possible route to future opportunities. If you want to help someone, by all means do so. But don’t mislead people. Let them down right away and it will be less painful than leading them on.
For example, a man may approach you and ask if you could help him find a U.S. market for his kente goods. You may think that sounds fun so you would say yes you would. Many months will pass and you will pursue a few leads, but got no idea what you will be doing was as with time, you become too busy to do it and in the end feel horribly guilty, when in reality you shouldn’t have gotten his hopes up by promising to do something you had zero experience in.
